This is the first study to determine the extent and nature of any sex differences in the ability of endothelial function to predict CVD events.Endothelial function has been shown to be a highly sensitive marker for the overall cardiovascular risk of an individual.Furthermore, there is evidence of important sex differences in endothelial function that may underlie the differential presentation of cardiovascular disease (CVD) in women relative to men.
Medical history, CVD risk factors, health behaviours, psychological status, and gender identity were assessed via structured interview or self-report questionnaires at baseline.
In addition, FHR was assessed, as well as levels of sex hormones via blood draw.
Patients will be followed for 5 years to assess major CVD events (cardiac mortality, non-fatal MI, revascularization procedures, and cerebrovascular events).
women using a novel, noninvasive nuclear medicine -based approach.
It is hypothesised that: 1) endothelial dysfunction will be a significant predictor of 5-year CVD events independent of baseline stress test results, clinical, demographic, and psychological variables in both men and women; and 2) endothelial dysfunction will be a better predictor of 5-year CVD events in women compared to men.